AustralieFrV1, Main, Exploration, bibRecord, 00B615

Pathophysiologic and therapeutic importance of tissue ACE: A consensus report

Identifieur interne : 00B615 ( Main/Exploration ); précédent : 00B614; suivant : 00B616

Pathophysiologic and therapeutic importance of tissue ACE: A consensus report

Auteurs : Victor J. Dzau [États-Unis] ; Kenneth Bernstein [États-Unis] ; David Celermajer [Australie] ; Jerome Cohen [États-Unis] ; Björn Dahlöf [Suède] ; John Deanfield [Royaume-Uni] ; Javier Diez [Espagne] ; Helmut Drexler [Allemagne] ; Roberto Ferrari [Italie] ; Wiek Van Gilst [Pays-Bas] ; Lennart Hansson [Suède] ; Burkhard Hornig [Allemagne] ; Ahsan Husain [Australie] ; Colin Johnston [Australie] ; Harold Lazar [États-Unis] ; Eva Lonn [Canada] ; Thomas Lüscher [Suisse] ; John Mancini [Canada] ; Albert Mimran [France] ; Carl Pepine ; Ton Rabelink ; Willem Remme ; Luis Ruilope ; Marcel Ruzicka ; Heribert Schunkert ; Karl Swedber ; Thomas Unger ; Douglas Vaughan ; Michael Weber

Source :

Cardiovascular drugs and therapy [ 0920-3206 ] ; 2002.

RBID : Pascal:02-0586490

Descripteurs français

Pascal (Inist)
- Peptidyl-dipeptidase A, Activité enzymatique, Angiotensine II, Remodelage vasculaire, Inflammation, Endothélium, Vaisseau sanguin, Appareil circulatoire, Système renin angiotensine, Myocarde, Coeur, Article synthèse, Appareil circulatoire pathologie, Physiopathologie, Azote monoxyde, Vaisseau sanguin pathologie, Inhibiteur angiotensin converting enzyme, Peptide, Mécanisme action.

English descriptors

KwdEn :
- ACE inhibitor, Angiotensin II, Blood vessel, Cardiovascular disease, Circulatory system, Endothelium, Enzymatic activity, Heart, Inflammation, Mechanism of action, Myocardium, Nitric oxide, Pathophysiology, Peptides, Peptidyl-dipeptidase A, Renin angiotensin system, Review, Vascular disease, Vascular remodeling.

Abstract

Angiotensin-converting enzyme (ACE) activation and the de novo production of angiotensin II contribute to cardiovascular disease through direct pathological tissue effects, including vascular remodeling and inflammation, as well as indirect action on nitric oxide bioavailability and its consequences. The endothelium plays a pivotal role in both vascular function and structure; thus, the predominant localization of ACE to the endothelium has implications for the pathobiology of vascular disease, such as coronary artery disease. Numerous experimental studies and clinical trials support the emerging realization that tissue ACE is a vital therapeutic target, and that its inhibition may restore endothelial function or prevent endothelial dysfunction. These effects exceed those attributable to blood pressure reduction alone; hence, ACE inhibitors may exert an important part of their effects through direct tissue action. Pharmacologic studies show that while ACE inhibitors may differ according to their binding affinity for tissue ACE the clinical significance remains to be determined.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 005548
to stream PascalFrancis, to step Curation: 000B91
to stream PascalFrancis, to step Checkpoint: 005300
to stream Main, to step Merge: 00C421
to stream Main, to step Curation: 00B615

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Pathophysiologic and therapeutic importance of tissue ACE: A consensus report</title>
<author><name sortKey="Dzau, Victor J" sort="Dzau, Victor J" uniqKey="Dzau V" first="Victor J." last="Dzau">Victor J. Dzau</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Medicine, Brigham Women's Hospital</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Boston, MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bernstein, Kenneth" sort="Bernstein, Kenneth" uniqKey="Bernstein K" first="Kenneth" last="Bernstein">Kenneth Bernstein</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Pathology and Laboratory Medicine, Emory University School of Medicine</s1>
<s2>Atlanta, GA</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Atlanta, GA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Celermajer, David" sort="Celermajer, David" uniqKey="Celermajer D" first="David" last="Celermajer">David Celermajer</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Medicine, University of Sydney, c/o Department of Cardiology, Royal Prince Alfred Hospital</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Cohen, Jerome" sort="Cohen, Jerome" uniqKey="Cohen J" first="Jerome" last="Cohen">Jerome Cohen</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Internal Medicine, Saint Louis University School of Medicine</s1>
<s2>Saint Louis, MO</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Saint Louis, MO</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dahlof, Bjorn" sort="Dahlof, Bjorn" uniqKey="Dahlof B" first="Björn" last="Dahlöf">Björn Dahlöf</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Medicine, Sahlgrenska University Hospital/Ostra</s1>
<s2>Nilssonsberg</s2>
<s3>SWE</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Nilssonsberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Deanfield, John" sort="Deanfield, John" uniqKey="Deanfield J" first="John" last="Deanfield">John Deanfield</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Great Ormond Street Hospital for Children, Vascular Physiology Unit</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Diez, Javier" sort="Diez, Javier" uniqKey="Diez J" first="Javier" last="Diez">Javier Diez</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Universidad de Navarra, Unidad de Fisiopatologia Vascular, Edificio de Ciencias, Calle Iruniarrea</s1>
<s2>Pampalona</s2>
<s3>ESP</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pampalona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Drexler, Helmut" sort="Drexler, Helmut" uniqKey="Drexler H" first="Helmut" last="Drexler">Helmut Drexler</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Department of Cardiology Medizinische Hochschule Hannover</s1>
<s2>Hannover</s2>
<s3>DEU</s3>
<sZ>8 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ferrari, Roberto" sort="Ferrari, Roberto" uniqKey="Ferrari R" first="Roberto" last="Ferrari">Roberto Ferrari</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Clinical and Experimental Medicine, Nuove Cliniche</s1>
<s2>Corso Ferrara</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Corso Ferrara</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Gilst, Wiek" sort="Van Gilst, Wiek" uniqKey="Van Gilst W" first="Wiek" last="Van Gilst">Wiek Van Gilst</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Department of Clinical Pharmacology, University Hospital, Groningen</s1>
<s2>Groningen</s2>
<s3>NLD</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hansson, Lennart" sort="Hansson, Lennart" uniqKey="Hansson L" first="Lennart" last="Hansson">Lennart Hansson</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Clinical Hypertension Research, University of Uppsala</s1>
<s2>Uppsala</s2>
<s3>SWE</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Uppsala</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hornig, Burkhard" sort="Hornig, Burkhard" uniqKey="Hornig B" first="Burkhard" last="Hornig">Burkhard Hornig</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Department of Cardiology Medizinische Hochschule Hannover</s1>
<s2>Hannover</s2>
<s3>DEU</s3>
<sZ>8 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Husain, Ahsan" sort="Husain, Ahsan" uniqKey="Husain A" first="Ahsan" last="Husain">Ahsan Husain</name>
<affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Victor Chang Cardiac Research Institute, Darlinghurst</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Johnston, Colin" sort="Johnston, Colin" uniqKey="Johnston C" first="Colin" last="Johnston">Colin Johnston</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Baker Institute</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lazar, Harold" sort="Lazar, Harold" uniqKey="Lazar H" first="Harold" last="Lazar">Harold Lazar</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Cardiothoracic Surgery, Boston Medical Center</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Boston, MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lonn, Eva" sort="Lonn, Eva" uniqKey="Lonn E" first="Eva" last="Lonn">Eva Lonn</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Division of Cardiology, HGH-McMaster Clinic</s1>
<s2>Hamilton, Ontario</s2>
<s3>CAN</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Hamilton, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Luscher, Thomas" sort="Luscher, Thomas" uniqKey="Luscher T" first="Thomas" last="Lüscher">Thomas Lüscher</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Division of Cardiology, University Hospital Zurich</s1>
<s2>Zurich</s2>
<s3>CHE</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<wicri:noRegion>Zurich</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mancini, John" sort="Mancini, John" uniqKey="Mancini J" first="John" last="Mancini">John Mancini</name>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Department of Medicine, Vancouver General Hospital</s1>
<s2>Vancouver, BC</s2>
<s3>CAN</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Vancouver, BC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mimran, Albert" sort="Mimran, Albert" uniqKey="Mimran A" first="Albert" last="Mimran">Albert Mimran</name>
<affiliation wicri:level="3"><inist:fA14 i1="18"><s1>Hospital Lapeyronie, Medecine Interne et Hypertension Arterielle, Centre Hospitalier, Universitaire</s1>
<s2>Montpellier</s2>
<s3>FRA</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pepine, Carl" sort="Pepine, Carl" uniqKey="Pepine C" first="Carl" last="Pepine">Carl Pepine</name>
</author>
<author><name sortKey="Rabelink, Ton" sort="Rabelink, Ton" uniqKey="Rabelink T" first="Ton" last="Rabelink">Ton Rabelink</name>
</author>
<author><name sortKey="Remme, Willem" sort="Remme, Willem" uniqKey="Remme W" first="Willem" last="Remme">Willem Remme</name>
</author>
<author><name sortKey="Ruilope, Luis" sort="Ruilope, Luis" uniqKey="Ruilope L" first="Luis" last="Ruilope">Luis Ruilope</name>
</author>
<author><name sortKey="Ruzicka, Marcel" sort="Ruzicka, Marcel" uniqKey="Ruzicka M" first="Marcel" last="Ruzicka">Marcel Ruzicka</name>
</author>
<author><name sortKey="Schunkert, Heribert" sort="Schunkert, Heribert" uniqKey="Schunkert H" first="Heribert" last="Schunkert">Heribert Schunkert</name>
</author>
<author><name sortKey="Swedber, Karl" sort="Swedber, Karl" uniqKey="Swedber K" first="Karl" last="Swedber">Karl Swedber</name>
</author>
<author><name sortKey="Unger, Thomas" sort="Unger, Thomas" uniqKey="Unger T" first="Thomas" last="Unger">Thomas Unger</name>
</author>
<author><name sortKey="Vaughan, Douglas" sort="Vaughan, Douglas" uniqKey="Vaughan D" first="Douglas" last="Vaughan">Douglas Vaughan</name>
</author>
<author><name sortKey="Weber, Michael" sort="Weber, Michael" uniqKey="Weber M" first="Michael" last="Weber">Michael Weber</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">02-0586490</idno>
<date when="2002">2002</date>
<idno type="stanalyst">PASCAL 02-0586490 INIST</idno>
<idno type="RBID">Pascal:02-0586490</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">005548</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000B91</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">005300</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">005300</idno>
<idno type="wicri:doubleKey">0920-3206:2002:Dzau V:pathophysiologic:and:therapeutic</idno>
<idno type="wicri:Area/Main/Merge">00C421</idno>
<idno type="wicri:Area/Main/Curation">00B615</idno>
<idno type="wicri:Area/Main/Exploration">00B615</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Pathophysiologic and therapeutic importance of tissue ACE: A consensus report</title>
<author><name sortKey="Dzau, Victor J" sort="Dzau, Victor J" uniqKey="Dzau V" first="Victor J." last="Dzau">Victor J. Dzau</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Medicine, Brigham Women's Hospital</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Boston, MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bernstein, Kenneth" sort="Bernstein, Kenneth" uniqKey="Bernstein K" first="Kenneth" last="Bernstein">Kenneth Bernstein</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Pathology and Laboratory Medicine, Emory University School of Medicine</s1>
<s2>Atlanta, GA</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Atlanta, GA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Celermajer, David" sort="Celermajer, David" uniqKey="Celermajer D" first="David" last="Celermajer">David Celermajer</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Medicine, University of Sydney, c/o Department of Cardiology, Royal Prince Alfred Hospital</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Cohen, Jerome" sort="Cohen, Jerome" uniqKey="Cohen J" first="Jerome" last="Cohen">Jerome Cohen</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Internal Medicine, Saint Louis University School of Medicine</s1>
<s2>Saint Louis, MO</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Saint Louis, MO</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dahlof, Bjorn" sort="Dahlof, Bjorn" uniqKey="Dahlof B" first="Björn" last="Dahlöf">Björn Dahlöf</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Medicine, Sahlgrenska University Hospital/Ostra</s1>
<s2>Nilssonsberg</s2>
<s3>SWE</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Nilssonsberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Deanfield, John" sort="Deanfield, John" uniqKey="Deanfield J" first="John" last="Deanfield">John Deanfield</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Great Ormond Street Hospital for Children, Vascular Physiology Unit</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Diez, Javier" sort="Diez, Javier" uniqKey="Diez J" first="Javier" last="Diez">Javier Diez</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Universidad de Navarra, Unidad de Fisiopatologia Vascular, Edificio de Ciencias, Calle Iruniarrea</s1>
<s2>Pampalona</s2>
<s3>ESP</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pampalona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Drexler, Helmut" sort="Drexler, Helmut" uniqKey="Drexler H" first="Helmut" last="Drexler">Helmut Drexler</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Department of Cardiology Medizinische Hochschule Hannover</s1>
<s2>Hannover</s2>
<s3>DEU</s3>
<sZ>8 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ferrari, Roberto" sort="Ferrari, Roberto" uniqKey="Ferrari R" first="Roberto" last="Ferrari">Roberto Ferrari</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Clinical and Experimental Medicine, Nuove Cliniche</s1>
<s2>Corso Ferrara</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Corso Ferrara</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Gilst, Wiek" sort="Van Gilst, Wiek" uniqKey="Van Gilst W" first="Wiek" last="Van Gilst">Wiek Van Gilst</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Department of Clinical Pharmacology, University Hospital, Groningen</s1>
<s2>Groningen</s2>
<s3>NLD</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hansson, Lennart" sort="Hansson, Lennart" uniqKey="Hansson L" first="Lennart" last="Hansson">Lennart Hansson</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Clinical Hypertension Research, University of Uppsala</s1>
<s2>Uppsala</s2>
<s3>SWE</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Uppsala</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hornig, Burkhard" sort="Hornig, Burkhard" uniqKey="Hornig B" first="Burkhard" last="Hornig">Burkhard Hornig</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Department of Cardiology Medizinische Hochschule Hannover</s1>
<s2>Hannover</s2>
<s3>DEU</s3>
<sZ>8 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Husain, Ahsan" sort="Husain, Ahsan" uniqKey="Husain A" first="Ahsan" last="Husain">Ahsan Husain</name>
<affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Victor Chang Cardiac Research Institute, Darlinghurst</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Johnston, Colin" sort="Johnston, Colin" uniqKey="Johnston C" first="Colin" last="Johnston">Colin Johnston</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Baker Institute</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lazar, Harold" sort="Lazar, Harold" uniqKey="Lazar H" first="Harold" last="Lazar">Harold Lazar</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Cardiothoracic Surgery, Boston Medical Center</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Boston, MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lonn, Eva" sort="Lonn, Eva" uniqKey="Lonn E" first="Eva" last="Lonn">Eva Lonn</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Division of Cardiology, HGH-McMaster Clinic</s1>
<s2>Hamilton, Ontario</s2>
<s3>CAN</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Hamilton, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Luscher, Thomas" sort="Luscher, Thomas" uniqKey="Luscher T" first="Thomas" last="Lüscher">Thomas Lüscher</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Division of Cardiology, University Hospital Zurich</s1>
<s2>Zurich</s2>
<s3>CHE</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<wicri:noRegion>Zurich</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mancini, John" sort="Mancini, John" uniqKey="Mancini J" first="John" last="Mancini">John Mancini</name>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Department of Medicine, Vancouver General Hospital</s1>
<s2>Vancouver, BC</s2>
<s3>CAN</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Vancouver, BC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mimran, Albert" sort="Mimran, Albert" uniqKey="Mimran A" first="Albert" last="Mimran">Albert Mimran</name>
<affiliation wicri:level="3"><inist:fA14 i1="18"><s1>Hospital Lapeyronie, Medecine Interne et Hypertension Arterielle, Centre Hospitalier, Universitaire</s1>
<s2>Montpellier</s2>
<s3>FRA</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pepine, Carl" sort="Pepine, Carl" uniqKey="Pepine C" first="Carl" last="Pepine">Carl Pepine</name>
</author>
<author><name sortKey="Rabelink, Ton" sort="Rabelink, Ton" uniqKey="Rabelink T" first="Ton" last="Rabelink">Ton Rabelink</name>
</author>
<author><name sortKey="Remme, Willem" sort="Remme, Willem" uniqKey="Remme W" first="Willem" last="Remme">Willem Remme</name>
</author>
<author><name sortKey="Ruilope, Luis" sort="Ruilope, Luis" uniqKey="Ruilope L" first="Luis" last="Ruilope">Luis Ruilope</name>
</author>
<author><name sortKey="Ruzicka, Marcel" sort="Ruzicka, Marcel" uniqKey="Ruzicka M" first="Marcel" last="Ruzicka">Marcel Ruzicka</name>
</author>
<author><name sortKey="Schunkert, Heribert" sort="Schunkert, Heribert" uniqKey="Schunkert H" first="Heribert" last="Schunkert">Heribert Schunkert</name>
</author>
<author><name sortKey="Swedber, Karl" sort="Swedber, Karl" uniqKey="Swedber K" first="Karl" last="Swedber">Karl Swedber</name>
</author>
<author><name sortKey="Unger, Thomas" sort="Unger, Thomas" uniqKey="Unger T" first="Thomas" last="Unger">Thomas Unger</name>
</author>
<author><name sortKey="Vaughan, Douglas" sort="Vaughan, Douglas" uniqKey="Vaughan D" first="Douglas" last="Vaughan">Douglas Vaughan</name>
</author>
<author><name sortKey="Weber, Michael" sort="Weber, Michael" uniqKey="Weber M" first="Michael" last="Weber">Michael Weber</name>
</author>
</analytic>
<series><title level="j" type="main">Cardiovascular drugs and therapy</title>
<title level="j" type="abbreviated">Cardiovasc. drugs ther.</title>
<idno type="ISSN">0920-3206</idno>
<imprint><date when="2002">2002</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Cardiovascular drugs and therapy</title>
<title level="j" type="abbreviated">Cardiovasc. drugs ther.</title>
<idno type="ISSN">0920-3206</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ACE inhibitor</term>
<term>Angiotensin II</term>
<term>Blood vessel</term>
<term>Cardiovascular disease</term>
<term>Circulatory system</term>
<term>Endothelium</term>
<term>Enzymatic activity</term>
<term>Heart</term>
<term>Inflammation</term>
<term>Mechanism of action</term>
<term>Myocardium</term>
<term>Nitric oxide</term>
<term>Pathophysiology</term>
<term>Peptides</term>
<term>Peptidyl-dipeptidase A</term>
<term>Renin angiotensin system</term>
<term>Review</term>
<term>Vascular disease</term>
<term>Vascular remodeling</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Peptidyl-dipeptidase A</term>
<term>Activité enzymatique</term>
<term>Angiotensine II</term>
<term>Remodelage vasculaire</term>
<term>Inflammation</term>
<term>Endothélium</term>
<term>Vaisseau sanguin</term>
<term>Appareil circulatoire</term>
<term>Système renin angiotensine</term>
<term>Myocarde</term>
<term>Coeur</term>
<term>Article synthèse</term>
<term>Appareil circulatoire pathologie</term>
<term>Physiopathologie</term>
<term>Azote monoxyde</term>
<term>Vaisseau sanguin pathologie</term>
<term>Inhibiteur angiotensin converting enzyme</term>
<term>Peptide</term>
<term>Mécanisme action</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Angiotensin-converting enzyme (ACE) activation and the de novo production of angiotensin II contribute to cardiovascular disease through direct pathological tissue effects, including vascular remodeling and inflammation, as well as indirect action on nitric oxide bioavailability and its consequences. The endothelium plays a pivotal role in both vascular function and structure; thus, the predominant localization of ACE to the endothelium has implications for the pathobiology of vascular disease, such as coronary artery disease. Numerous experimental studies and clinical trials support the emerging realization that tissue ACE is a vital therapeutic target, and that its inhibition may restore endothelial function or prevent endothelial dysfunction. These effects exceed those attributable to blood pressure reduction alone; hence, ACE inhibitors may exert an important part of their effects through direct tissue action. Pharmacologic studies show that while ACE inhibitors may differ according to their binding affinity for tissue ACE the clinical significance remains to be determined.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Canada</li>
<li>Espagne</li>
<li>France</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Basse-Saxe</li>
<li>Grand Londres</li>
<li>Groningue (province)</li>
<li>Languedoc-Roussillon</li>
<li>Nouvelle-Galles du Sud</li>
<li>Occitanie (région administrative)</li>
<li>Victoria (État)</li>
</region>
<settlement><li>Groningue</li>
<li>Hanovre</li>
<li>Londres</li>
<li>Melbourne</li>
<li>Montpellier</li>
<li>Sydney</li>
</settlement>
<orgName><li>Université de Sydney</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Pepine, Carl" sort="Pepine, Carl" uniqKey="Pepine C" first="Carl" last="Pepine">Carl Pepine</name>
<name sortKey="Rabelink, Ton" sort="Rabelink, Ton" uniqKey="Rabelink T" first="Ton" last="Rabelink">Ton Rabelink</name>
<name sortKey="Remme, Willem" sort="Remme, Willem" uniqKey="Remme W" first="Willem" last="Remme">Willem Remme</name>
<name sortKey="Ruilope, Luis" sort="Ruilope, Luis" uniqKey="Ruilope L" first="Luis" last="Ruilope">Luis Ruilope</name>
<name sortKey="Ruzicka, Marcel" sort="Ruzicka, Marcel" uniqKey="Ruzicka M" first="Marcel" last="Ruzicka">Marcel Ruzicka</name>
<name sortKey="Schunkert, Heribert" sort="Schunkert, Heribert" uniqKey="Schunkert H" first="Heribert" last="Schunkert">Heribert Schunkert</name>
<name sortKey="Swedber, Karl" sort="Swedber, Karl" uniqKey="Swedber K" first="Karl" last="Swedber">Karl Swedber</name>
<name sortKey="Unger, Thomas" sort="Unger, Thomas" uniqKey="Unger T" first="Thomas" last="Unger">Thomas Unger</name>
<name sortKey="Vaughan, Douglas" sort="Vaughan, Douglas" uniqKey="Vaughan D" first="Douglas" last="Vaughan">Douglas Vaughan</name>
<name sortKey="Weber, Michael" sort="Weber, Michael" uniqKey="Weber M" first="Michael" last="Weber">Michael Weber</name>
</noCountry>
<country name="États-Unis"><noRegion><name sortKey="Dzau, Victor J" sort="Dzau, Victor J" uniqKey="Dzau V" first="Victor J." last="Dzau">Victor J. Dzau</name>
</noRegion>
<name sortKey="Bernstein, Kenneth" sort="Bernstein, Kenneth" uniqKey="Bernstein K" first="Kenneth" last="Bernstein">Kenneth Bernstein</name>
<name sortKey="Cohen, Jerome" sort="Cohen, Jerome" uniqKey="Cohen J" first="Jerome" last="Cohen">Jerome Cohen</name>
<name sortKey="Lazar, Harold" sort="Lazar, Harold" uniqKey="Lazar H" first="Harold" last="Lazar">Harold Lazar</name>
</country>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Celermajer, David" sort="Celermajer, David" uniqKey="Celermajer D" first="David" last="Celermajer">David Celermajer</name>
</region>
<name sortKey="Husain, Ahsan" sort="Husain, Ahsan" uniqKey="Husain A" first="Ahsan" last="Husain">Ahsan Husain</name>
<name sortKey="Johnston, Colin" sort="Johnston, Colin" uniqKey="Johnston C" first="Colin" last="Johnston">Colin Johnston</name>
</country>
<country name="Suède"><noRegion><name sortKey="Dahlof, Bjorn" sort="Dahlof, Bjorn" uniqKey="Dahlof B" first="Björn" last="Dahlöf">Björn Dahlöf</name>
</noRegion>
<name sortKey="Hansson, Lennart" sort="Hansson, Lennart" uniqKey="Hansson L" first="Lennart" last="Hansson">Lennart Hansson</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Deanfield, John" sort="Deanfield, John" uniqKey="Deanfield J" first="John" last="Deanfield">John Deanfield</name>
</region>
</country>
<country name="Espagne"><noRegion><name sortKey="Diez, Javier" sort="Diez, Javier" uniqKey="Diez J" first="Javier" last="Diez">Javier Diez</name>
</noRegion>
</country>
<country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Drexler, Helmut" sort="Drexler, Helmut" uniqKey="Drexler H" first="Helmut" last="Drexler">Helmut Drexler</name>
</region>
<name sortKey="Hornig, Burkhard" sort="Hornig, Burkhard" uniqKey="Hornig B" first="Burkhard" last="Hornig">Burkhard Hornig</name>
</country>
<country name="Italie"><noRegion><name sortKey="Ferrari, Roberto" sort="Ferrari, Roberto" uniqKey="Ferrari R" first="Roberto" last="Ferrari">Roberto Ferrari</name>
</noRegion>
</country>
<country name="Pays-Bas"><region name="Groningue (province)"><name sortKey="Van Gilst, Wiek" sort="Van Gilst, Wiek" uniqKey="Van Gilst W" first="Wiek" last="Van Gilst">Wiek Van Gilst</name>
</region>
</country>
<country name="Canada"><noRegion><name sortKey="Lonn, Eva" sort="Lonn, Eva" uniqKey="Lonn E" first="Eva" last="Lonn">Eva Lonn</name>
</noRegion>
<name sortKey="Mancini, John" sort="Mancini, John" uniqKey="Mancini J" first="John" last="Mancini">John Mancini</name>
</country>
<country name="Suisse"><noRegion><name sortKey="Luscher, Thomas" sort="Luscher, Thomas" uniqKey="Luscher T" first="Thomas" last="Lüscher">Thomas Lüscher</name>
</noRegion>
</country>
<country name="France"><region name="Occitanie (région administrative)"><name sortKey="Mimran, Albert" sort="Mimran, Albert" uniqKey="Mimran A" first="Albert" last="Mimran">Albert Mimran</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 00B615 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 00B615 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:02-0586490
   |texte=   Pathophysiologic and therapeutic importance of tissue ACE: A consensus report
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

Pathophysiologic and therapeutic importance of tissue ACE: A consensus report

Pathophysiologic and therapeutic importance of tissue ACE: A consensus report

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri